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  1. People

Richard A Steinman, MD, PhD

  • Associate Professor of Medicine/Pharmacology

Education & Training

  • BS: Haverford College, 1978
  • M.D.: University of Pennsylvania, 1987
  • Ph.D.: University of Pennsylvania, 1988

Representative Publications

Steinman RA, Yang Q, Gasparetto M, Robinson X, Liu DE, Lenzner E, Jou J, Smith C, Wang Q. "Deletion of the RNA-Editing Enzyme ADAR1 Causes Regression of Established Chronic Myelogenous Leukemia in Mice,". International Journal of Cancer. 2013; 132(8): 1741-50.

Steinman RA, Brufsky AM, Oesterreich S. "Zoledronic acid effectiveness against breast cancer metastases-a role for estrogen in the microenvironment?". Breast Cancer Research. 2012; 14: 213.

Steinman RA, Robinson A, Feghali-Bostwick C. "Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts". PloSOne. 2012; 7: e48560.

Ernst J, Ghanem L, Bar-Joseph Z, Brown J, McNamara M, Steinman RA. “IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability,”. PLoS One. 2009; 10: 7469.

Birru M, Steinman RA. “Online Health Information and Low-literacy African Americans,”. Medical Internet Research. 2004; 6: 109-114.

Birru MS, Monaco VM, Drew H, Njie V, Bierria T, Detlefsen E, Steinman RA. "Observational Analysis of Internet Usage by Low-Literacy Adults Seeking Health Information,". Journal of Medical Internet Research. 2004; 6: 67-78.

Steinman RA, Wentzel A, Lu Y, Stehle C, Grandis JR. Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2,. Oncogene. 2003; 5: 3608-15.

Yaroslavskiy B, Watkins S, Stolz D, Bradbury N, Alba S, Steinman RA. Anti-Apoptotic Action of p21WAF1 Involves Stabilization of c-IAP1 Protein Expression. Molecular Medicine. 2001; 7: 49-58.

Steinman RA, Johnson D. p21 Inhibits Differentiation in 32Dcl3 Cells. Molecular Medicine. 2000; 6: 736-749.

Steinman RA, Huang JP, Yaroslavskiy B, Goff JP, Ball ED, Nguyen A. Regulation of p21(Waf1) during myelopoiesis. Blood. 1998; 91: 4531-4532.

Research Interests

Dr. Steinman's laboratory studies the cancer microenvironment with a focus on the molecular and functional interactions between cancer cells, fibroblasts and platelets. He has developed novel tools to enable fluorescent labeling and desired planned genetic recombination of normal cells that are next to cancer cells, making it possible for normal cells that were in the path of cancer cells to be isolated and characterized for cancer-induced collaborative signals. Through this approach he seeks to uncover and to dissect the impact of signaling pathways on tumor-stromal co-evolution. He also studies tumor dormancy, modeling factors in host stromal cells that could contribute to breast cancer recurrence and conversion to estrogen receptor negativity in bone. His study of communication between cancer and normal cells also includes work on platelets, in which his laboratory has identified an unexpected pathway that appears to be necessary for platelets to bind to cancer cells and support their spread. Dr. Steinman is currently PI on 3 NIH grants as well as a DoD grant