- Research Areas
Current research projects at the TTMRC
- Ancillary to ABC PICU to Study MODs in Critically Ill Children (TRAP MODs) (08/01/17 – 04/30/22)
- Pediatric Traumatic Hemorrhagic Shock Consensus Conference and Research Priorities. (04/01/20 – 03/31/22)
- Chilled Platelet Study Clinical Trial and In Vitro Platelet Quality Characterization Project. (09/25/20 – 09/24/25)
- Field-Optimized Composition and Use for ErythroMer (Artificial Red Cell). (09/01/20 – 08/31/22)
- Pathogen Inactivated Lyophilized Cryoprecipitate for Prehospital Hemostatic Resuscitation. (07/01/21 – 06/30/24)
- ErythroMer: Nanoscale Bio-Synthetic Red Cell Substitute. (05/11/1-05/31/21)
- Utilization of Thromboelastography to Monitor Rivaroxaban Activity in Trauma and Emergency Surgery. (03/01/2016-02/28/2019)
- Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After Trauma. (09/01/2016-05/31/2021)
- SynthoPlate Nanotechnology For Intravenous Hemostasis and Wound Healing in Prolonged Field Care. (09/30/2017-09/29/2020)
- Strategies to Promote ResiliencY (SPRY-1) - A UPMC REMAP Initiative. (2/1/18 7/31/19)
- Testing for Platelet Inhibition before and after platelet transfusion in Traumatic Brain Injury (TPI-TBI). (01/01/2018-12/31/2020)
- Pragmatic, Prehospital Group O Whole Blood early Resuscitation Pilot Trial. (07/01/2017-05/31/2020)
- Linking Investigations in Trauma and Emergency Services (LITES). W81XWH-16-D-0024
- Analysis and Characterization of Trauma-Induced Coagulopathy. (06/01/2018-05/31/2019)
- Engineering Biologic Topography into Vascular Grafts. (09/15/2018-08/31/2019)
Jason L. Sperry
- Pragmatic, Prehospital Group O Whole Blood Early Resuscitation Pilot Trial(PPOWER). (07/2017–05/2020)
- Linking Investigations in Trauma and Emergency Services (LITES) Network. (09/30/2016-09/29/2025)
- Role of erythroid DAMP molecules in the pathogenesis of vascular injury in sepsis. (02/1/2015-01/31/2020)
- Analysis and Characterization of Trauma Induced Coagulopathy. (09/01/2013- 08/30/19)
- Training in Trauma and Sepsis Research. (07/01/2009-06/30/2019)
- Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis. (05/01/2018-04/30/2023)
- A Novel Regulation of the Phase II Enzyme Estrogen Sulfotranferase. (08/01/2014-04/30/2019)
- Immunometabolism in Sepsis. (07/15/2015-05/31/2019).
- Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis. (09/30/2017-09/29/2021)
- A Precision Medicine Approach based on Discrete Time Windows for Predicting Outcomes of Polytrauma Patients. (01/01/2018-12/31/2020)
- Role of erythroid DAMP molecules in the pathogenesis of vascular injury in sepsis. (04/01/2015-03/31/2020)
- Mitochondria as Immune Regulators in Sepsis. (11/01/2017-10/30/2021).
- Analysis and Characterization of Trauma Induced Coagulopathy. (09/01/2013-08/30/19).
- CAMK: Central regulators of the response to surgical sepsis. (05/01/2017-04/30/2019).
- Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction after Trauma. (11/01/2016-10/30/2021).
- Study of Tranexamic Acid During Air Medical Prehospital Transport Trial (STAAMP Trial). (02/01/2015-01/30/2019).
- Modeling of Cytokine Networks and Gene Expression Profiles Mediating Rejection in Vascularized Composite Allotransplantation. (07/01/15 – 06/30/19)
- Palliative care intervention for socioeconomically disadvantaged cancer patients. (06/01/15 -05/31/19)
- The Major Extremity Trauma and Rehabilitation Research Consortium. (07/01/16 –06/30/21)
- Detailed Analysis of the Inflammatory Milieu of Patients Receiving a Left Ventricular Assist Device. (04/01/17 – 10/31/18)
- Technology Assisted Stepped collaborative Care Intervention (TASCCI) to Improve Patient-centered Outcomes in Hemodialysis Patients. (07/05/17 – 06/30/22)
- Modeling Brainstem Inflammation's Role in Systemic Dysfunction during Sepsis. ( 04/01/17 – 03/31/22)
- Surgery triggered immune response and liver metastases (04/01/17 – 03/31/22)
- A Precision Medicine Approach Based on Discrete Time Windows for Predicting Outcomes of Polytrauma Patients. (01/01/18 – 12/31/21)
- Immune Fingerprinting Signatures in Predicting Successful Aging. (01/01/19 – 12/31/22)
- Inflammasome activation in trauma/ hemorrhagic shock. (07/01/12-12/30/22)
- Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell disease (06/01/19-03/31/24)
- Phenytypic Renal Cases in Sepsis and surgery for Early Acute Kidney Injury (PReCISE AKI). NIH/NIDDK (07/01/2017 – 06/30/2022)
- Blue light protects against ischemia-induced organ injury. (09/20/2016 – 06/30/2020)
- CAMK: Central Regulators of the response to surgical sepsis. (08/03/2015 – 07/31/2019)
- Developing a novel intervention to make physician heuristics a source of power (10/01/2015 – 09/30/2020)
- Cell Priming, Receptor Cross-talk, and Acute Lung Injury/\
- Macrophage Pyroptosis Mechanism of Post-Trauma Acute Lung Injury
- Improvement of Organ Function after Severe Hypovolemia
- Cell Death Mechanism of Acute Lung Injury in Sepsis
- PXR-mediated xenobiotic response in the pathogenesis hemorrhagic shock
- A Novel regulation of the phase ii enzyme estrogen sulfotransferas